Recombinant ( yeast ) hepatitis B vaccine the composition and characters of strain by recombinant yeast expressing hepatitis B virus surface antigen ( HBsAg ) ,purified plus adjuvant adsorbing material.
Vaccine for white suspension ,due to precipitation and stratification ,Yi Yao scattering ,should not be not shake loose clumps. size this product per ampoule for 0.5ml.Each with a dose of 0.
5ml, including HbsAg5ug. this product is based on the quality standard of Chinese requirements for biological products ( 2000 EDITION) standards of production and testing ,to meet the quality requirements .
the role and use of vaccination ,can stimulate the body to produce on hepatitis B virus immunity ,use in the prevention of hepatitis B vaccination . object this vaccine for hepatitis B in susceptible persons, particularly the following 
1)neonates ,especially mother HBsAg ,HBeAg positive subjects ;( 2)engaged in medical work of the medical personnel and in contact with the blood of experimental staff.
usage and dosage ( 1)the vaccination at the time to fully shake .( 2)upper arm deltoid muscle injection site .( 3)first needle in neonatal birth within 24 hours after injection .
1 months and 6months afterinjection of second ,3 needles,other population immunity program for zeroth ,1,and 6 months ,the dose was 5ug /branch . taboo suffering from fever ,acute or chronic severe diseases and on yeast allergies are prohibited.
side reaction and treatment of the few adverse reactions ,others may have ,in the low-grade fever or injection of local pain ,24 hoursaway . note ( 1)before use shake .( 2),have not shake powder ampoule breaking blocks shall not be used.
( 3)should be prepared epinephrine ,to prevent the occasional allergic reaction occurs . preservation ,transportation and use the term 2-8C was preserved in the dark, to prevent freezing.
In box label or label indicating the failure period use of BCG Bacillus Calmette-Guerin Vaccine . alias tuberculosis drug live vaccine ,freeze dried BCG vaccine for intradermal injection BCG ,B.
C.G.Vaccine this product is a molecular formula composition by Leon Calmette and Camile Guerin initiative, this is the use of BCG strains in culture medium ,collecting membrane ,suspension for proper sterilization protection liquid, after freeze drying is made.
The live bacteria preparation, has produced antibodies ,enhance immunity ,induced by G interference in the role. And freeze dried vaccine live bacteria counting per mg should be in 1000000 above ,intradermal injection with diluted 1mL,each containing 0 5-1mg specifications preparation powder :0.
5mg ~0.75mgbacteria .This product freeze dried powder injection is white loose solid or powder ,join 1mL injection waterfor 2 minutescompletely dissolved as homogeneous suspension ,residual moisture content should not exceed 3% .
Freeze dried BCG injection for 10 storagemethod :/. Stored in the 2-8 Cdark. Period :1 years.BCG oral suspension in 10mg:1mL.Oral BCG 1mL:50mg.Scratch BCG (1) 0.5mL:37.5mg( 2)1mL:75mgBCG vaccine for intradermal injection ( 1)1mL:0.
5mg( 2)1mL:0.75mg( 3)2mL: 1.5mg. This injection into a milky white suspension ,pH 6.8-7.6,placed after the sinking of the bacteria ,and can be evenly dispersed . in pharmacology and toxicology of tubercle bacilli are intracellular parasitic bacteria ,so the body anti tuberculosis specific immune predominantly cellular immune .
BCG vaccination is made of nontoxic BCG ( Bacillus) artificial vaccination for the first time after infection ,macrophage processing ,the antigens to immune cells, T cells ,formation of sensitized lymphocytes ,when the body to meet a mycobacterial infection ,macrophage and lymphocyte sensitization is activated rapidly ,execution of immune function, induce a specific immune response .
Because release of lymph Is the son of sensitized lymphocytes immune function, which chemokine ( MCF ) can attract macrophages and neutrophil polymorphonuclear leukocytes ,which tends to antigenic substance and sensitized lymphocyte interactions in the parts move ,macrophage inhibitory factor ( MIF ) can inhibit the entry of inflammatory zone macrophages and neutrophil polymorphonuclear leukocytes to move ,so that they stay in inflammation or pathogen aggregation site ,to play a role in the occurrence of macrophages .
MIF adhesive ,and the phagocytic response significantly increased .Macrophage activating factor ( MAF ) main function is increased macrophage phagocytic and digestive ability ,and enhance macrophage antigen processing ability ,thereby enhancing the immunogenicity of antigens role.
Therefore in mycobacterial involved sites ,macrophages appear to condense, phagocyte lots of tubercle bacilli. In mycobacterial growth inhibitory factor effect, can inhibit the intracellular mycobacterial growth ,and digestion ,finally wiped out ,forming a tuberculosis specific immunity in BCG .
Enter the organism ,elicit specific immune responses at the same time ,also create a wide range of nonspecific immune function ,and T cells to produce lymphokines ,T cells themselves direct killing effect and body Humoral factors interact .
The clinical application of :1 bornwithin 3 months of the baby and with 5IUPPD ( PPD tuberculin purified protein derivative ) or 5IU old tuberculin test negative for children ( PPD or negative tuberculin skin test after 48-72 hours,local induration in the following 5mm is negative ) ,intradermal inoculation for the prevention of tuberculosis.
2isused in the treatment of malignant melanoma ,or in the lung ,acute leukemia ,malignant lymphoma radical operation or chemotherapy as adjuvant treatment after ,have a certain effect. 3 deadBCG also for prevention of cold in children ,pediatric asthma treatment of arthritis and the prevention and treatment of adult chronic gas Zhi Qiguan and arthritis.
pharmacokinetics college after inoculation of 4-8weeks toproduce immunity ,immunity could maintain 3-4 years. indications tuberculosis prevention ,vaccination for birth within 3 months of the baby or the old negative tuberculin skin test in children.
adverse reaction of vaccination week 2 local swelling,infiltration ,fester ,and formed small ulcers ,serious person should take the appropriate treatment .I can occur following vaccination reactions: ( 1)1-2 after inoculationwith lymphadenitis :a month or so ,the neck ,axillary ,supraclavicular lymph nodes ( or greater than 1 0cm ) .
After the reaction ,lymphadenopathy ,form abscess or broken ,or in the vaccination has small pus blisters .The intradermal injection reaction is often scratch method is strong ,while the old tuberculin ( OT ) test positive ,after vaccination can also be generated strong reaction .
( 2)class of lupus response :with mycobacterial strains residual virulence .( 3)scar :because of abundant granulation tissue formation of scar protrusions ,sometimes scarred aneurysm ,see more on OT test and direct percutaneous scar vaccinated .
1immuneinhibitor interactions ( such as cyclosporine ,tacrolimus ,sirolimus ,leflunomide .) :immunosuppression will lead to decreased immunity ,immunity after vaccination with live bacteria will cause serious and even fatal infections .
2glucocorticoids:conventionally, high-dose glucocorticoids (daily dosage over 10mgprednisolone or equivalent to other corticosteroids ,continuously for more than 2 weeks ) induced immune suppression in patients ,should not receive less vaccine .
Lots of steroid induced immunosuppression of attenuated vaccine of incomplete response .But glucocorticoid and low – dose ,short-term ( less than 14 days)for systemic use ;local use ;or low – dose ,short-acting corticosteroid long-term substitution rule Healing and joint ,bursa ,Achilles tendon glucocorticoid injections should not be regarded as vaccination contraindications.
Replacement therapy in the treatment of steroid dose ,such as Addison disease ,immune to the effects of theophylline .3:BCG vaccination can significantly improve the average plasma half-life of theophylline .
Most patients will experience a transient and mild plasma theophylline levels rise period . deltoid muscle lateral intradermal injection of 0.1ml. Childrenintradermal injection of the 1 vaccinedelivery note no subcutaneous or intramuscular injection of BCG vaccination .
2do not usethe same syringe ,avoid hepatitis infectious rate increased .The ampoule crack or expired can not be used. The 3 and other vaccine at the same time when in use should not be on the same side injection.
The 4 vaccinationand tuberculosis patient isolation even after 2 months,in order to avoid during which infected . 2-3 monthsafter positive tuberculin test ,said the success of vaccination ,negative to replant.
After every 3-4 annual revaccinationonce, multiple cropping the former should also make a tuberculin skin test .5 onimmunity in patients with reduced after chemotherapy with viable vaccination will cause serious and even fatal infections .
Chemotherapy stop and accept live vaccination among Interval of at least 3 months.6 ifafter injection appears in the treatment of scar ,avoid operation excision ,can be combined with local block therapy ,the hydrocortisone acetate 12.
5mg,100-300mg isoniazid,0.5%procaine solution amount, after mixing with the sterilized syringe mixing liquid for local injection ,2 times per week,for 10 consecutive times in 2 weeks ,stop ,continue to injection ,until the scar knot in the mind becomes flat until about 2 weeks after vaccination .
7localredness infiltration ,if the subsequent suppuration ,forming a small ulcer, available 1% gentiansmear to prevent infection ,general 8-12 weekscab ;in case of locoregional lymph nodes can be hot processing ;as has been softened to form pustules.
,available syringe aspiration ;such as perforation available 10% sulfonamide ointment or 20%amino salicylic acid ointment treatment .8 useproducts should pay attention to avoid light ,live vaccine with no exposure to sunlight .
9 intradermalimmunization must not be injected into subcutaneous ,otherwise it will cause serious deep abscess ,prolonged unhealed. Injection high doses can cause vaccination abscess or lymphadenitis ,should follow the recommended dose.
10vaccinated subjectsmust be detailed to register the name ,sex ,age ,home address ,vaccine batches and batches ,manufacturing units and date of vaccination .Preparation of 11 this productshould wear gloves ,masks ,gowns .
Containing the vaccine containers ,syringes and other items may not be used for other injection ,to prevent suppurative reaction .Discarded before disinfection. 12freeze driedinjection vaccine dilution method: use the sterilized syringe with 1mLattached to the dilution of the products demand accurate suction to freeze dried BCG ampoules ,placed 1 minutes aftershaking the ampoule to melt ,using a syringe and extraction times ,so that the full mixing .
Each ampoule from dilution ,must be in half an hour to run out ,to prevent contamination . note ,suffering from tuberculosis ,acute infectious disease heart kidney brain disease ,severe malnutrition ,eczema and other skin disease ,HIV infection or vaccination.
Before use as the tuberculin skin test ,negative shall be inoculated .Contraindications ( 1)tuberculosis ,acute infectious disease ,heart disease ,nephritis ,immune defects disease ,eczema or skin disease patients .
( 2)acute disease ,burn patients ,disease recovery period ( ending disease and health recovery between ) ,recent smallpox vaccination ,urinary tract infection patients. ( foreign material ) ( 3)due to the use of the drug or treatment due to suppression of immune response :Alkylating agent ,anti-metabolite ,radiotherapy ,steroids ( foreign data .
) ( 4)due to the following causes the immune response reduces :systemic malignancy ,infection of HIV ,G interference hormone receptor defects ,leukemia ,lymphoma .( foreign material ) ( 5)caused by infectious diseases of unknown etiology of fever or fever may use BCG .
( foreign material ) ( 6)reduced immunity in infants or children. ( foreign data ) using ( 1)strongly positive tuberculin reaction in the patients with caution. ( 2)in patients with asthma.
Immunogenic substances can cause asthma or allergic reactions .Oral live attenuated poliomyelitis vaccine composition and characters of oral polio vaccine dragee-candy take polio I ,II ,III type attenuated strains were inoculated in human diploid cell culture into trivalent vaccine dragee-candy ,white for the color .
For the prevention of poliomyelitis. size this product formulations for candy ,each using a dose of 1G heavycandy 1 tablets,containing live virus ( total 5.95LgTCID50or PFU) ,which type of 5.
8 LgTCID50 (or PFU ) ,type 4.8 LgTCID50(or PFU ) ,type III is 5.3 LgTCID50 (or PFU ) . this product is based on the quality standard of Chinese requirements for biological products 2000 editionof standards of production and testing ,to meet the quality requirements .
the role and use of oral immunization ,can stimulate the body to produce antibodies against poliovirus immunity ,for the prevention of poliomyelitis. object vaccination for more than 2 months old child .
administration and dosage first immune from February age began ,the first successive years of oral 3 times,each time interval of 4 ~ 6 weeks. 4 years tostrengthen immunization in 1 .The other age groups in need can also take taboo ,have a fever .
Acute infectious diseases ,immune defects in ,receiving immunosuppressive therapy and not to be taken by pregnant women . after oral side effects and treatment generally no side reaction ,others have a fever ,nausea ,vomiting ,diarrhea and rash .
In general do not need special treatment ,if necessary, symptomatic treatment. note ( 1)the product for oral administration, can not be injected .( 2)the strains of vaccine ,do not add in hot boiling water or hot food taking the preservation ,transportation and use .
period since the vaccine dragee-candy verification qualified date ,- 20 DEG Cbelow are valid for a period of 2 years,from 4 to 8DEG Cto save for a period of 5 months. Transport in cold storage conditions.
In box sign marked within the period of validity of using adsorption .Pertussis ,diphtheria ,tetanus and pertussis combined vaccine the role and use of vaccination ,can make the body produce humoral immune response .
For prevention of pertussis ,diphtheria ,tetanus . composition and the strains by pertussis vaccine diphtheria toxoid stock solution ,and purified tetanus toxoid by aluminum hydroxide adsorption material.
For the milky white suspension ,preservatives ,placed after adjuvant sinking ,shaking becomes homogeneous suspensions. standard this product is based on Chinese requirements for biological products in 2000 edition ofthe production and testing ,quality meet the requirements.
object vaccination 3 months- 6 year old children. usage the buttocks and upper 1 / 4 or thelateral upper arm deltoid insertion for skin disinfection after intramuscular injection.
The since March December age age, immune ,to finish 3 needleimmune ,each needle interval 4-6 weeks18-24months,fourth injection needle. Each injection dose of 0.5ml. has epilepsy ,neurological disorders and draft history is disabled .
The acute infectious diseases ( including recovery) and fever, the suspension of vaccination . side effects and treatment injection after the goods local swelling, pain ,itching ,or fever ,fatigue, headache ,generally do not need treatment shall subside.
E.g. Have a serious reaction to timely diagnosis and treatment. the use of well ,such as shake not dispersed clot ,foreign body ,ampoules with crack ,products have frozen ,the label is not clear and expired can not be used.
The induration after injection of local may have ,but gradually absorbed. The second injection needle should be replaced the other side parts .It should be prepared for adrenaline ,happen occasionally shock emergency use .
The first injection needle after the onset of high fever, convulsions and other abnormal situations, not the second injection needle . storage 2-8keep avoid lightand transportation ,can not be frozen.
No cell hundred ,white broken vaccine ,composition and properties this product is composed of acellular pertussis vaccine ,diphtheria toxoid and tetanus toxoid with aluminum hydroxide adsorption material, milky white suspension ,preservatives ,placed after adjuvant sinking ,shaking becomes homogeneous suspensions.
this product specifications the specifications for each 0.5ml.Each dosage ampoule containing pertussis potency of 0.5ml.Should be not less than 4.0IU;diphtheria potency should be not less than 30IU;Tetanus potency is not lower than 40IU.
this product is based on the quality standard of Chinese requirements for biological products in 2000 edition ofthe production and testing ,quality standards. the role and use of vaccination.
Later, can make the body produce humoral immune responses ,for the prevention of pertussis ,diphtheria ,tetanus vaccination . object 3 months~ 6 year oldchildren. usage and dosage ( 1)the buttock above 1 / 4 or thelateral upper arm deltoid attachment of skin with sterile after intramuscular injections ( 2.
Immunization program and dose ) based immune from March to December were age ,completed 3 needleimmunity ,0.5ml each time,each needle spacing 4 ~6 weeks;strengthen the immune usually in the basis of immunity after 18 ~ 24month of age,injection dose of 0.
5ml. taboo ( 1)have epilepsy ,mental illness and draft history is disabled. ( 2)acute infectious diseases ( including recovery) and fever, delayed injection adverse reactions and treatment .
this product is generally no reaction injection vaccination site ,some mild blush ,itching or have low heat ,generally do not need special treatment ,then subsided, such as have a serious reaction to timely diagnosis and treatment .
note ( 1)should be used to fully shake shake ,such as not scattered the clot ,foreign body ,ampoules with crack ,products have frozen ,label is not clear and expired can not be used.
( 2)after the injection of local may have induration ,can be absorbed gradually, the second injection needle should be replaced the other side ( 3)shall be prepared in kidney .Adrenergic ,happen occasionally shock for emergency use.
( 4)the first injection needle after the onset of high fever, convulsions and other abnormal situations, not the second injection needle . preservation ,transportation and use the term in 2~ 8lightstorage and transportation ,shall not be frozen .
In the box ( or label ) indicating sign within the validity of the use of attenuated live measles vaccine . the vaccine ,can stimulate the body to produce antibodies against measles virus immunity.
For the prevention of measles. composition and this strain with the measles virus attenuated strain of chicken embryos inoculated with cells ,cultured ,and add suitable harvest virus liquid stabilizer made from freeze-dried vaccine freeze-drying .
For cream color loose body ,dissolving after the orange Cheng prescribed liquid . standard this product is based on Chinese requirements for biological products 2000 editionof standards of production and testing ,to meet the quality requirements .
object vaccination age for more than 8 months of measles susceptibility usage . according to the label marked volume with sterile water for injection, be completely dissolved and shake before use .
Lateral upper arm deltoid attachment point with 75% alcohol disinfection of skin ,to be dried after subcutaneous injection ( 0.2mlto 0.5m1). suffering from serious illness ,acute or chronic infection ,fever or the eggs had Sensitive history not vaccinated .
side effects and treatment after injection in general no local reactions. In 6-10 days ,a few children may appear to have one of the febrile response and scattered rash ,generally not more than 2 days mayrelieve itself ,without special treatment ,if necessary, symptomatic treatment.
( 1open theampoule ) ( or vial ) and injection ,do not allow the disinfectant exposure vaccine .(2 )the ampoule crack ,label is not clear or not clear after the dissolution may be used.
( 3)the bottles of Kaifeng, the vaccine should be used up within 1 hours .( 4)injection of immune cells protein ,the interval should be 1months laterbefore inoculation of the vaccine . storage 2-8keep avoid light.
Freeze dried live attenuated varicella vaccine composition and characters of the vaccine ,take the international general varicella virus attenuated strain OKa ,MRC-5 human diploid cellculture is made.
A freeze-dried product appearance milky white loose body ,dissolved pale yellow liquid . size 1 servings/ boxes (containing the vaccine 1 bottle,1 bottlesof sterile water for injection.
) this vaccine according to quality standards approved by the state of the freeze dried live attenuated varicella vaccine to declare the standard production capacity ,to meet the quality requirements .
the vaccine can stimulate the body to produce antibodies against varicella disease Poison immunity ,for the prevention of varicella vaccination . object varicella susceptibility :mainly in December age – 12 years old healthy children.
usage 1,using the attached sterile water for injection of 0.5ml into the vaccine bottle completely dissolved and freeze dried vaccine .2,in the deltoid muscle attachment with disinfectant ,to be dry after subcutaneous injection of vaccine 0.
5ml / people . have serious disease history ,history of allergy ,the immune defects sick and disabled women. General disease treatment period ,fever corrosion . side effects and treatment inoculation of the vaccine without following the general reaction ,the inoculation of 6-18 daysa few people can have a short transient mild fever or rash ,generally subside on their own without treatment ,if necessary, can be symptomatic treatment .
( 1)the ampoule crack ,label is not clear or dissolved in the bottle after foreign body were not available .( 2)the vaccine bottle opening and do not allow the disinfectant exposure vaccine inoculation ;and should be used in the opening 30 minutesout .
( 3)injection of immune cells protein should be an interval of 1 months after inoculation of the vaccine .( 4)in women of childbearing age in the inoculation of the vaccine after at least 3 monthsshould contraception.
for preservation and transportation of 2-8keep avoid light,cold chain transportation .B Japanese encephalitis live attenuated vaccine the role and use of Following immunization ,can stimulate the body to produce resistance to Japanese encephalitis virus immunity ,for the prevention of epidemic encephalitis B .
composition and this product is made of Japanese encephalitis attenuated virus SAl4-14-2 vaccinationin primary hamster kidney cells ,cultured after harvesting virus liquid ,adding protecting agent for freeze dried made ,pale yellow loose body ,dissolved after the Cheng bright orange liquid .
standard this product is based on Chinese requirements for biological products 2000 editionof standards of production and testing ,in line with quality requirements. object August age or vaccination in healthy children and from non-endemic areas into the infected children and adult .
usage ( 1)and freeze dried vaccine before using, for each ampoule according to indicate the amount of added to the product configuration of the diluent .Be completely dissolved before use.
( 2)lateral upper arm deltoid attachment point with 75% alcohol for skin disinfection ,alcohol dry after subcutaneous injection of 0.5ml. 1(3)August first instar injection in children 0.
5m1;at the age of 2 to strengthen theinjection of 0.5m1 ;at the age of 7 after injection of0.5ml,is no longer immune . fever ,suffering from acute infectious disease ,otitis media ,active tuberculosis ,heart ,kidney and liver disease ,physical weakness ,have a history of allergy or epilepsy ,congenital immune defects ,the near future or positive During immunosuppressive therapy for patients and pregnant women should not be injected the vaccine side effects and treatment .
a few children may appear to have one of the febrile response ,generally not more than 2 days,and relieve itself. I have scattered in the appearance of the rash ,generally do not need special treatment ,if necessary, symptomatic treatment.
( 1)open bottles and injection do not use disinfectant exposure vaccine .The vaccine ( 2)after the dissolution of a shake does not come loose lump ,bottles crack or dissolved before vaccine to become red ,can not be used.
( 3)after the dissolution of vaccine should be used up within 1 hours ,out to be abandoned. Storage 8 DEG Cstored away from light .A meningococcal polysaccharide vaccine him the composition and characters of strains with A Neisseria bacteria culture fluid ,purified polysaccharide antigen and adding suitable for freeze-drying stabilizer made of the polysaccharide vaccine .
The finished product is white loose body ,adding the with PBS can be rapidly dissolved solution Cheng Ming ,no foreign body . this product specifications the specifications for each ampoule 300mg polysaccharide.
Each using dose containing 30mg . this product is based on the quality standard of Chinese requirements for biological products 2000 editionof standards of production and testing ,quality meet the requirements.
the role and use of vaccination after ,Can make the body produce humoral immune responses ,for prevention of group A meningococcal global strain of epidemic cerebrospinal meningitis caused by vaccination .
object 6 months~ 15 year oldchildren. usage and dosage ( 1)opened the vaccine bottle, each adding 5mlPBSsolution ,shake for immediate use. ( 2)the upper arm lateral deltoid muscle attachment after disinfection, subcutaneous injection of 0.
5ml ( 30mg) .( 3)immune children ranging in age from June age began ,basic vaccination 2 needles,each needle at intervals of 3 monthsabove 3 years old 1needleinoculation ,vaccination should be on epidemic cerebrospinal meningitis epidemic season before completion.
According to the need of multiple cropping 1 timesevery 3 years .In the case of epidemic situation, can enlarge the age group for emergency vaccination. taboo in any of the following circumstances ,do not use this vaccine .
( 1)epilepsy ,convulsion ,brain disorders and have a history of allergy .( 2)kidney disease ,heart disease and active tuberculosis .( 3)and acute infectious diseases fever . this vaccine side effects and treatment response to mild ,occasional transient fever, local slight pressure pain ,relieve itself.
note ( 1)should be inspected before use ampoule ampoules ,such as cracks ,loosening or bottle stopper foreign body inside ,shall not be used. ( 2)each ampoule products shall be dissolved ,for a time ( dose ) Run out of ,not scoring many times.
preservation ,transportation and use the term in 2~ 8lightpreservation and transportation. Since the freeze dried date is valid for 2 years,in the box ( label ) sign or mark used within its valid period .
Measles mumps rubella virus vaccine .. MMR II preparation of the vaccine specifications is used for immunization of live virus vaccines ,including measles ,mumps virus ,rubella virus attenuated .
Three kinds of virus are first mixed ,then freeze dried ,does not contain preservatives ,formulation ,a transparent yellow .In addition to the above-mentioned components ,the drug also contains about 25 mgneomycin ,a small amount of sorbitol and hydrolyzed gelatin as a stabilizer .
2-8oC ,stored away from light .After the vaccine formulation should be in the 2-8oCstored away from light .And used within 8 hours. in pharmacology and toxicology the vaccine is highly immunogenic ,susceptible population vaccinated once ,can induce 95%measles hemagglutination inhibition ( HI ) antibody ,neutralizing antibody and 99% 96%mumps rubella hemagglutination inhibition ( HI ) antibody .
The vaccine of RA27 / 3 strains of rubella virusin inoculated ,immediately after the induction of produce high levels of HI antibodies ,complement binding antibodies and neutralizing antibodies ,and more close to natural infection.
The vaccine induced high levels ,wide distribution Functional antibody ,resulting in a human body for subclinical infection virus has greater resistance ,and can extend the continuous duration of immunity, vaccination ,this vaccine induced antibodies can last more than 11 years.
indications 15 monthsabove the crowd ,immunization against measles ,mumps and rubella . adverse reaction injection site to appear short time of burning or tingling .Occasionally have a fever after inoculation of 5-12day,skin rash ,rare local swelling ,hardened and tenderness ,discomfort ,nausea, vomiting ,mumps ,diarrhea ,local lymph nodes, thrombocytopenia ,purpura ,allergic reactions ,joint pain and / or arthritis ,myalgia ,skin erythema multiforme ,optic neuritis ,including eye after neuritis ,papillitis ,retinitis ,conjunctivitis and ophthalmoplegia ,otitis media ,nerve deafness ,orchitis .
Children may present with seizures or epilepsy ,headache ,dizziness ,sensory abnormalities ,polyneuritis ,acute infectious polyneuritis ,movement dysregulation .Rare subacute sclerosing panencephalitis ( SSPE ) ,in these cases ,some may be due in the first postnatal year had undiagnosed measles or had received measles immunity ,because after inoculating with a measles vaccine produced by SSPE ,About one in a million ,which is much lower than the natural measles infection after the SSPE.
0.5 mL,subcutaneous injection into the upper arm . note 1pregnancywomen 2 to this medicineany component and / or the egg ( live measles and mumps vaccine is produced by chick embryo cell culture the ) hypersensitivity in 3 febriledisorders ,active ,untreated tuberculosis patients 4 underwentimmunosuppressive therapy the patient is disabled.
5blooddyscrasia ,leukemia ,lymphoma or other effects of bone marrow or lymph system in patients with malignant tumors. 6immunedefects ,including AIDS patients ,by the human immune defects caused by virus clinical polytrauma patients infected ,cells of the immune defects of patients ,such as blood gamma global protein in oligohydramnios and abnormalities in the patient ,the family is congenital or hereditary immune defects in history person ,only confirmed have immunity before vaccination.
Within 715 months of the infant from the mother due to a surplus of measles the presence of antibodies to measles vaccine ,the composition does not generate responses .About the difficulty of implementation of immunization programs in the remote areas of the population, and 15 months following natural measles infection in a high risk population ,Early vaccination is necessary.
In this case 12 monthspreviously immunized infants ,shall be 15 months again when the immune .8age in the 12-14months most ofthe baby is easier for the immune response ,in order to avoid these infants do not produce immune responses ,they learn to be added in after one vaccination .
There evidence that ,within 1 years of age infants after immunization, when again after immunization ,may not produce long-lasting antibody level again ,due to immune may occur when the immune response to early failure ,so the method of inoculation overall balance.
For not previously vaccinated against rubella vaccination of susceptible pregnant women infants should be given as soon as possible .The vaccine and other vaccines should be an interval of 1 months or more ,if necessary, at the same time DPT vaccination and injection of polio vaccine ,application of different syringe ,in different parts of vaccination.
Before vaccination should first prepare emergency measures for allergic reaction ,timely appropriate treatment .With a personal or family history ,history of febrile seizures in traumatic brain injury should be used with caution.
Infected with human immune defects virus in children and young adults ,but no obvious clinical symptoms can receive the vaccine ,but should be carefully monitored whether a patient suffering from this vaccine for Anti disease.
Transfusion of blood or plasma transfusion ,injection of human immune cells protein ,3months before thevaccination. The vaccine against others tuberculin skin tests may cause temporary inhibition, so do the tuberculin test ,should precede the vaccination or simultaneously.
On pregnancy and lactation effects on pregnancy women after vaccination is can cause fetal damage or affect the reproductive capacity is not clear ,therefore ,pregnant women should not be vaccinated, and vaccinated women in 3 monthsto avoid pregnancy .
Breast milk can secrete measles or mumps virus is unclear ,recent research shows that milk :women vaccinated with live attenuated rubella vaccine, breast milk can produce this kind of virus, and can spread to the baby ,your baby has confirmed these serum rubella infection ,but do not exhibit severe symptoms ,clinical typical manifestations of moderate acquired rubella infection ,so the milk woman careful with this vaccine .
Live attenuated hepatitis A vaccine Hepatitis A Vaccine .And the traits strains will hav attenuated strain inoculation of human diploid cells ,cultured ,harvested virus liquid and made.
The vaccine should be transparent ,Cheng Ming no foreign body fluids. Preparation of specification injection :1ml.Each with a dose of 1ml, containing live virus quantity should not be less than 6.
5LgCCID50. indications against hepatitis A vaccination . object aged above 1 years of age in patients with hepatitis a easy . upper arm deltoid subcutaneous injection ,each 1ml.