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Beijing Novartis Pharma AG’s new smoking cessation product mm Sunni r (nicotine transdermal system) recently listed in China.
Sunni r (nicotine transdermal system) in a foreign country more than ten years of clinical experience, is based on nicotine replacement therapy nicotine transdermal patch piece. Nicotine replacement therapy referred to NRT therapy, the World Health Organization (WHO) recommended mitigation smoking and smoking cessation treatment of choice. Nipah help quit smoking, reduce smokers a variety of addictive behaviors and withdrawal phenomena which directly absorb nicotine through the skin, the use of 8m10 hours after the steady-state plasma concentration of the blood concentration, after removal of transdermal nicotine, plasma nicotine concentration decreased slowly. Nipah r once daily, a one, the effective concentration can be maintained for 24 hours.
clinical trials: is the WHO recommended nicotine replacement therapy, the U.S. FDA approved and proven effective by evidence-based health Pok, safety, adverse drug reactions and mild method to quit smoking ; the United States in 1996, the Ministry of Health issued in the country, form part of the original offer to get nicotine from cigarettes, and far below the therapeutic dose of nicotine from cigarettes in the amount of gain, can reduce withdrawal symptoms when quitting smoking, improving the success rate of quitting smoking, avoiding smoking produced harmful substances (such as: carbon monoxide and tar) on the body of poison. NRT therapy after extensive clinical studies to effectively control the cravings and ease the symptoms during smoking cessation, smoking cessation success rate is about twice the placebo.
Nicotine replacement therapy research began in the 1970s, has been widely used in the international arena a long time, people’s understanding of nicotine there is a misunderstanding: that the way through the smoke inhaled nicotine causes cancer, but in 1988 U.S. medical experts, studies have shown that nicotine is not carcinogenic, but the resulting substance addiction, tobacco combustion of a variety of harmful substances hazardous to health is the culprit of these harmful substances contained as many as more than 40 carcinogens .
greatest harm is that it is nicotine addiction, and the role very quickly, inhalation only 7.5 seconds to reach the brain. Once addicted smokers, each smoking a cigarette 30m40 minutes required to maintain the brain stable level of nicotine, when not reach this level, smokers may feel tired Zao, discomfort, nausea, headache and eager to add nicotine, that nicotine dependence, also known as physical dependence or outright stop smoking if smoking occurs restlessness, irritability, anxiety, depression, difficulty concentrating, insomnia, decreased heart rate, increased appetite and other symptoms of tobacco withdrawal. nicotine dependence include psychological dependence, manifested as a strong smoke desire, also known as the replacement therapy is currently the most widely used method of treatment which one can make smokers dependent on nicotine and gradually decreasing at the same time, but also to avoid burning due to inhalation of harmful substances in tobacco, thus avoiding the risk of chronic diseases and cancer the possibility of using Sunni smokers (nicotine transdermal system), the only to avoid the hazards of harmful substances in tobacco, but also to eliminate or reduce smoking withdrawal therapy when the tough, easy to help smokers quit. Nicotine in cigarettes is a major component leading to addiction, nicotine dependence is the main reason smokers can not get rid of addiction.
Sunni r patch is based on nicotine replacement therapy to quit smoking patch, generic name transdermal nicotine transdermal patch. patch is circular, attached to the square on the protection foil, remove the protective foil, showing uniform yellow film adhesion surface. The product according to the area of ​​contact with the skin is divided into three specifications (Sunni r patch 10,20,30).
Sunni r is the role of patch to help quit smoking, nicotine-dependent smokers to reduce addictive behavior and withdrawal symptoms.
Sunni r patch is smokers by reducing the physiological dependence on nicotine to quit smoking.
Sunni r patch stability by giving a small amount of nicotine in the body to break the cycle of nicotine addiction.
Sunni r by gradually ease smokers to quit smoking ways to achieve the purpose of thoroughly.
Sunni r patch use after quitting smoking, can effectively reduce the incidence of smoking-related diseases.
Sunni r good security patch, no significant adverse response.
was surveyed 1,000 households, found that smoking families of children under the age of 16 suffering from respiratory disease than non-smoking families have 0.5 children, no smoking in the home, 33.5% respiratory symptoms, and there are 44.5% of smoking households with respiratory symptoms. Children exposed to environmental tobacco smoke on children’s health can have significant and widespread adverse effects, including lower respiratory tract infections such as pneumonia and bronchitis, cough and asthma, aggravation of asthma and middle ear disease, and even cause death. this effect in all cones are present. childhood exposure to environmental tobacco smoke may also lead to adult cardiovascular disease and nervous system damage.
Canadian study, women started smoking in adolescence and non-smoking women compared to day troubles to be higher than the rate of breast cancer Ji 2 / 3 of British Columbia, Vancouver, Canada Pierre Chelsea cancer research institutions. Bender and colleagues, of 1,000 adult women with breast cancer and 1,000 healthy women were compared and found that five years after menarche than non-smoking women began smoking women suffering from this disease increased by 69% wind Yan. Because breast cells in women at puberty, when a more robust stage of development, this period of breast cells to tobacco carcinogens is most sensitive, easily affected.
a medical Pok study shows that smokers infected with meningeal inflammation, sepsis, pneumonia and ear diseases of Ji higher rate than non-smokers 4 times more surgery as a treatment, while the balance of the body causing damage to the environment, the body’s defenses against pathogens decreases, while For long-term smokers of their post-surgical infection bacteria likely than non-smokers 2.5 times higher, so the patients before and three days to a week after a few weeks should be prohibited from smoking.
tobacco mainly by carbohydrates ( accounted for 40% m50%) acids, pigments, terpenes material, alkanes, lipid composition of substances, as well as some of the growth process in its own essential nutrients (such as nitrate, etc.) and some of the pollution (eg, pesticides, heavy metals, etc.). tobacco and other plants important difference is the material contained terpenes rich, known as the Smoke consists of two parts, which occupy some 92% of the gas, including large amounts of oxygen and nitrogen, a certain amount of carbon monoxide and trace amounts of carcinogens, tumor promoters, cilia toxic substances; particulate part of the 8%, mainly nicotine and cigarette tar.
cigarette smoke is the main component of the harmful carbon monoxide, nicotine and tar cigarettes which carbon monoxide and smoke tars are the main cause disease, nicotine only lead to hidden.
tobacco ingredients
carbon monoxide-induced disease

circulatory, respiratory system hypoxia, leading to myocardial damage, arrhythmias, pulmonary hypertension and other
smoke contains tar
Ji one hundred kinds of curb harmful substances directly irritation and damage to the respiratory tract mucosa, causing chronic bronchitis; and one of the many carcinogens can directly cause cancer.
nicotine
increased sympathetic activity and lead to addiction.
pharmacology of nicotine Role: main role of nicotine in the central nervous system nicotinic acetylcholine receptor (nAChR), mainly Nl cholinergic receptors. just finished cigarette smoking, smokers, plasma nicotine concentration in the short term peaks, then gradually down and plasma elimination half-life of nicotine about 2h, after half-life by more than 1, the plasma nicotine concentration dropped to a certain level, reaching the value of craving, then, of nicotine on the mesolimbic dopamine system (sympathetic nervous system) is weakened, in lack of endogenous Ach release, resulting in lack of dopamine release, Ca2 + transmembrane influx reduction, which led to a series of withdrawal symptoms, including thinking, concentration, anxiety, trouble Zao, headache, drowsiness, heart rate, blood pressure, lower blood sugar, hunger, brain wave abnormalities, endocrine (ACTH, ADH) disorders, etc., namely, sense, or in advance in order to prevent withdrawal symptoms of smoking, which is the root cause of smoking addiction. ease the addiction is an important part of disease treatment, is the first step to quit smoking completely.
a large number of studies have shown that smoking desire and behavior is blood through the body to regulate levels of nicotine, smoking Houniguding into the blood, acting on the central nervous system nicotinic acetylcholine receptors (cholinergic receptors mainly N1), the central nervous system stimulant Long-term stimulation of nicotine cholinergic receptor number N1 and sensitivity to change, the body balance in this state once flatly to stop smoking without using nicotine replacement therapy (such as the Sunni r patch), the body’s nicotine level will decrease the intensity of stimulation of nicotinic receptors decreased, while up to a certain extent it will trigger a series of physiological changes, quit smoking withdrawal symptoms will be the following: thinking, concentration, anxiety, trouble Zao , headache, drowsiness, heart rate, blood pressure, blood glucose decreased, hunger, brain wave abnormalities, endocrine (ACTH, ADH) disorders, etc. namely, craving, smokers will have a strong desire to smoke, eventually leading to cessation failure.
transdermal nicotine replacement therapy is affixed by means of giving a small amount of nicotine agent that nicotine addiction levels of serum maintained at a certain level, to avoid fluctuations in the level of serum nicotine, nicotine reduces the body’s desire to achieve gradually ease smoking, and by gradually reducing the amount of nicotine into the deterrence, and ultimately achieve complete remission addiction that is the purpose of smoking cessation.
nicotine replacement therapy (NRT) in the role of smoking cessation in smokers mm to help ease the plasma level of nicotine in a certain range fluctuation is caused by addiction causes. smoking a cigarette can make the plasma nicotine levels rose rapidly from the lowest point to the peak, then decreased gradually until it reaches the value of craving, smokers have cravings at this time and this kinds of repeated cycles of formation of physical dependence on nicotine.’s desire to break this cyclical reaction is the key to break the physiological addiction, smoking cessation is the key to use Sunni r, the plasma remained relatively stable above the value of the concentration of nicotine withdrawal symptoms, reduce the degree of desire to smoke. all smokers, Ji almost 90% of smokers are nicotine dependent, and only 10% of smokers are smoking or quit smoking even thou no withdrawal symptoms.
Sunni r patch as recommended by WHO to ease smoking and smoking cessation nicotine replacement therapy, can effectively relieve cravings, and the purpose of achieving the complete cessation of clinical trials
nicotine replacement therapy to quit smoking can be triple the success rate.
NRT is not a magic treatment, it is not completely replace smoking or substitute for willpower, but when smokers want to quit and do some restraint when, NRT can weaken their ring off symptoms, help to ease the desire of smoking, so smokers can more smoothly and physiological changes in smoking habits of this life.
NRT give a small amount of nicotine, but it is safer than smoking and less addictive.
Although NRT given nicotine, but compared and cigarettes, it does not contain tar and carbon monoxide, but also no evidence that nicotine can cause cancer.
Although the NRT does not completely eliminate the tension, irritability, depression and other withdrawal symptoms, but can partially ease.
NRT and a handful of people because of addiction, some smokers continue to use one or two years mainly because of the fear once again smoking.
smoking for a long time and number of NRT works best people, give it enough time smokers to change their ingrained habits, recommended period of 12 weeks.
Sunni r patch mechanism to break the drug cycle of nicotine addiction, Use Sunni r, the ex-smokers by transdermal, sustained and stable access to small amounts of nicotine, so they will not stop smoking and lead to reduced plasma concentrations of nicotine, but remain slightly higher than the relatively stable craving nicotine plasma concentration values, thus avoiding the emergence of withdrawal symptoms, which broke the cycle of nicotine addiction. to change the existing nicotine tolerance, high-dose through 12 weeks from the decreasing use of small doses of nicotine Most rely on physiological responses will be weakened, the desire of smokers to nicotine was reduced.
Sunni r patch of pharmacokinetic Pok
Sunni r each piece contains 17.5mg of nicotine patch 10, the active substance released into the skin of the average speed of 7mg/24h
Sunni r each piece contains 35.0mg of nicotine patch 20, the active substances released into the skin of the average speed of 14mg/24h
Each Sunni r patch 30 contains 52.5mg of nicotine, the active substances released into the skin, the average speed of 2lmg/24h
Sunni r patch released within 24h continuous low-dose nicotine, nicotine can be absorbed through the skin rapidly, spread into the blood circulation, maintaining a relatively value higher than the craving stable plasma concentrations of nicotine, so smokers desire degree of nicotine significantly reduced. Nicotine also distributed in other body tissue. on the application of Sunni r patch of healthy smokers study found that, in plasma nicotine levels gradually increased to peak after the first 1 – 2 hours slow decline in the level of nicotine in the patch application Sunni r 8 – 10 hours after the plasma level of nicotine into the plateau in Figure 6 below:
after Sunni r professional smoking cessation program after treatment, plasma nicotine levels drop faster than the intravenous infusion of nicotine half-life of 2 hours to clear more slowly. Nipah r patch of active substance (nicotine) into the blood circulation of about 10% using Sunni r quit posted plasma nicotine levels after 20 fluctuation range is 7.1 ng / mLm12.1 ng / mL; with Sunni r patch 30 after the fluctuation range of plasma nicotine levels 10.3ng / mLm17.7 ng / mL. are smoking less than fluctuations in plasma nicotine levels after cigarette range.
nicotine through the blood brain barrier, placental barrier, in amniotic fluid, umbilical cord blood were detected, in addition to breast milk in smoking mothers measured in circulating plasma protein binding was nicotine is less than 5%, all plasma nicotine clearance range 0.92m2.43 L / min.
nicotine primarily by hepatic metabolism, a small part of the lung metabolism, very few of the prototype non-renal excretion of metabolites in the form from its metabolites hydroxylation mainly 3rm cotinine renal excretion of nicotine depends on the amount of urine and urine PH value, when Ji in alkaline urine excreted almost no nicotine.’s half-life of nicotine in the body varies, an average of 2 hours (1m3.5 hours).
Sunni r patch characteristics and use of Sunni r patch nicotine absorbed through the skin directly, using the 8m10 hours after the plasma concentration reached steady-state plasma concentrations after patch removal, The slow decline in plasma concentrations. once a day, once a patch, can be effective concentration for 24 hours. Nipah r patch should be attached to the clean, dry, intact skin (the skin should be no detergents, alcohol or residual ointment), affixed with the best parts of the trunk, upper arm or buttocks. pasting press with the palm after 10 seconds a day should be chosen with different parts of the paste.
use patch from the start, smoking on request are completely stopped smoking is recommended before going to bed at night the first time. The patch applies to adults over the age of 18 years at the end of treatment, if the patch still does not make it stop smoking, you should stop using. patch can not be cut or torn. showers, bathing, swimming can still be used.
patch smoking cessation therapy to ease Sunni r smoking cessation programs are recommended by WHO smoking cessation programs, including the following Ji points:
Sunni r quit posted by reducing the smoker’s physical dependence on nicotine to quit smoking.
QUIT professionally trained consultant to help resolve the psychological curb on smoking issues.
health care specialists to support increased the likelihood of success.
Sunni r patch specific smoking cessation treatments and gradually the number of daily smokers of more than 20 heavy smokers should choose Sunni r patch 30, 10-20 number of daily smokers support of moderate Sunni smokers should choose r patch 20, less than 10 daily smokers of light smokers should choose Sunni r patch 10
Sunni r patch of clinical research and application
Sunni r patch 30 with three weeks, can effectively relieve cravings, but also the basis for completely quit smoking.
are heavy smokers, for example by following these steps:
first Sunni-week selection phase 1m4 r patch 30
week of the second phase of 5m8 r patch selection Sunni 20
week of the third stage 8m12 r chosen Sunni Sunni patch 10
r allows smoking who move out of dependence on nicotine, should be used with tapering. recommended period of 9-12 weeks, the dose should be used for each phase of 3-4 weeks.
Sunni r patch of clinical research and application of
Sunni Clinical efficacy of r patch confirmed Nipah r patch efficacy was significantly better than relying solely on the will to quit smoking, double-blind trial that the use of Sunni r chances of success are two to three times the placebo. Steven study: Sunni r compared with placebo patch for smoking cessation success rate of placebo 3.8 times the study: Sunni r compared with the placebo patch for smoking cessation success rate of placebo and 2.7 times. Fiore study : Sunni r compared with placebo patch for smoking cessation success rate with placebo was 2.1 times. Tzivoni study: Sunni r compared with the placebo patch for smoking cessation success rate with placebo was 2.1 times
Sunni r patch to use the proceeds
short-term gains Sunni r patch to quit smoking during and after the purpose of short-term gains: 20 minutes mm blood pressure and pulse rate return to normal hours of .8 mm carbon monoxide levels in plasma decreased by half, with oxygen back to normal, the patient improved physical fitness, energy conscious days, .1 mm lung and bronchial secretions
Sunni r clear patch of clinical research and application of
2 天 mm to improve the sensitivity of taste and smell
3 天 m breathe, the trachea began to expand
2-12 weeks mm to improve the blood circulation system features to improve lung function
3-9 mm 月 10%
complete cessation of long-term gains the most fundamental purpose of caused by smoking is to reduce the incidence of related diseases.
Sunni r patch with long-term gains after:
1 mm die from coronary heart disease risk was reduced 50%
2-3 Yan years mm women’s risk of coronary heart disease decreased with age Yan considerable level of non-smoking women
10 years, died of lung cancer risk Yan mmm reduced 30-50%
10-20 mm die-year risk of any disease Yan and non-smokers fell to a considerable level of
Sunni r patch use after effectively reduce the incidence of disease incidence of chronic bronchitis, decreased by 29%, and emphysema for more than 27% reduction in the incidence , the incidence of coronary heart disease decreased by 25% or more.
Sunni r patch of clinical research and application
using Sunni r patch, it can effectively reduce chronic bronchitis, chronic obstructive pulmonary emphysema , lung cancer, hypertension, myocardial infarction, the incidence of other diseases, and relieve associated symptoms of long-term smokers, smoking, use in the perioperative period, Sunni r patch, you can get such as reducing the postoperative infection rate and many other benefits.
Sunni r the difference between drugs and other clinical NRT studies Sunni r24-hour film and 16 hours of clinical trials comparing
film the latest clinical trials showed that about 75% of smokers in the wake 30 minutes, smoke your first cigarette.
this desire is the first cigarette smokers most difficult to overcome difficulties.
24 小时 film can reduce the desire to smoke early in the morning, so when the plasma has been a certain level of nicotine.